Chikwata chemasayendisiti chepasi rose chinotungamirwa neSeville chakakwanisa kugadzira simbi nanoparticles inokwanisa kuuraya mabhakitiriya eStaphylococcus aureusUtachiona uhwu, hunokonzera hutachiona hwakawanda hunowanikwa muzvipatara uye hunoratidza kuramba kuri kuramba mishonga inorwisa mabhakitiriya, hwakasimbiswa murabhoritari uye huri kutariswa senzira inogona kushandiswa kurwisa zvinonzi "superbugs," chimwe chezvinetso zvikuru zvehutano muzvipatara muSpain nedzimwe nyika dzeEurope.
Tsvagiridzo iyi, yakarongwa neInstitute of Chemical Research, iyo iri nzvimbo yakabatana ye CSIC neYunivhesiti yeSevilleInokurudzira nzira yakasiyana yekurapa mabhakitiriya ekare: mishonga inorwisa utachiona yebiomimetic, yakafuridzirwa nemaitiro echisikigo uye yakavakwa kubva nanomaterials dzakasanganiswa ne organic biomoleculesKunyangwe ichiri muchikamu chekuyedza, chidzidzo ichi chinoisa hwaro hwekurapa mune ramangwana kunonangana nehutachiona hwakakomba nedzimwe zvirwere uko kusagona kurwisa chirwere ichi kuri kuwedzera dambudziko.
Chirongwa chekuEurope chekudzivirira hutachiona husingarapike muzvipatara
Basa iri rakaitwa nekuda kwekushandira pamwe pakati pemasangano akati wandei ekuEurope nenzvimbo yeGerman, nehutungamiriri hwakajeka hweAndalusian. Pamwe chete neInstitute of Chemical Research, zvinotevera zvakatora chikamu: Universidade Nova de Lisboa (Portugal), University of Toulouse (France), Leibniz Institute for Natural Product Research uye Infection Biology (Germany) uye Autonomous University of Barcelona.Nzvimbo idzi dzinoratidza kunetseka kuripo muEurope nezvehutachiona hwemunocomial uye kurasikirwa nekushanda kwemishonga inorwisa mabhakitiriya.
Mabhakitiriya akatarisana neongororo iyi, Staphylococcus aureusStaphylococcus aureus ndeimwe yezvikonzero zvikuru zvehutachiona hunokonzerwa nehutano, kubva pamatambudziko eganda kusvika kuzvirwere zvakakomba zvakaita sepneumonia kana hutachiona panzvimbo yekuvhiyiwa. Dzimwe mhando dzayo, dzakadai semethicillin-resistant Staphylococcus aureus (MRSA), dzave dambudziko guru muzvipatara zvakawanda nekuda kwekusapindura kwayo zvakanyanya kumishonga inorwisa mabhakitiriya inoshandiswa zvakanyanya.
Vakatarisana nemamiriro ezvinhu aya, timu yakatsvaga kugadzira mumiriri aizoshanda inoshanda pakurwisa mabhakitiriya ane matambudziko, asi inosarudza uye ine chepfu shomaNemamwe mashoko, hurongwa husingazorwisi zvimwe tupukanana tunobatsira mumuviri kana kukurudzira kukura kwekusagona kurwisa utachiona. Kusanganiswa uku kwesimba uye kunyatsoshanda ndicho chimwe chezvinangwa zvikuru zvekutsvaga mishonga inorwisa utachiona pari zvino.
Chidzidzo ichi chakaburitswa munyaya yesainzi mujenari reInorganic Chemistry, iro rinotsanangura chimiro che nanoparticles, maitiro ekugadzira kwavo, uye kuyedza kwakaitwa kuyera mashandiro avo. Chirongwa ichi chakatsigirwawo nemari kubva [kusangano/sangano rakakodzera]. Bazi reMayunivhesiti, Tsvagiridzo neKugadzira Zvinhu Zvitsva reHurumende yeDunhu reAndalusia uye nemari inobva kuInstitute of Chemical Research pachayo.
Zvikamu zviviri zvisina mushonga wekurwisa mabhakitiriya zvinoshanda pamwe chete
Pfungwa huru yebasa iri yakavakirwa pamusanganiswa uyo, pakutanga, ungaratidzika kunge unopesana nepfungwa: simbi nemorekuru yeorganic izvo zvakasiyana hazviratidze basa rekuuraya utachionaAsi kana zvikasanganiswa pachiyero chidiki, zvinova chinhu chinokwanisa kubvisa Staphylococcus aureus. Nzira iyi inotsamira pakushanda pamwe chete, uko kushandira pamwe pakati pezvikamu zvese kunogadzira chinhu chitsva.
Kune rumwe rutivi, vaongorori vanoshandisa zvidimbu zvidiki zvikuru zveruthenium nanoparticlesRuthenium, simbi inowanzoshandiswa mumakemikari uye catalysis kuti ikurumidze kuita kwemakemikari, ndeimwe yezvikamu. Imwe inosanganisira molekyuru yeorganic inobva kuuracil, hwaro huripo mumajini ezvisikwa zvipenyu. Kunyangwe ruthenium kana uracil derivative iyi isingashande semushonga unorwisa mabhakitiriya wega, maitiro avo anochinja zvachose kana akabatanidzwa muchimiro chimwe chete.
Zvidimbu zvidiki zvinobuda zvakaputirwa nemorekuru iyi yeorganic, iyo inoshanda se ligand chaiyo pamusoro pesimbi. Chidzidzo ichi chinotsanangura kuti nzira iyi yekubatanidza inogadzira nharaunda chaiyo yemakemikari yakakomberedza simbi, iyo inotarisira kugona kusarudza kurwisa mabhakitiriya eStaphylococcus aureusSisitimu iyi inoshanda sekunge mudziyo wakagadzirwa nemaoko, wakagadzirwa zvakanaka kuti uzive uye ukuvadze rudzi rwakati rwetupukanana.
Sekureva kwevanyori, mhedzisiro inoonekwa haitsanangurwi chete nekuvapo kwesimbi kana biomolecule, asi nekuti zvinobatana sei pa nanoscale. Nzira iyi yekugadzira zvinhu zvinorwisa utachiona, ichitsvaga kushandira pamwe pakati pezvikamu zvakasiyana-siyana "zvinoita sezvisina basa" chimwe nechimwe, inowira mukati mezvinonzi nzira dzebiomimetic, dzinoedza kutevedzera kana kufemerwa nemhinduro dzakagadzirwa nezvisikwa pachazvo mukushanduka-shanduka kwezvinhu.
Pamusoro pekukosha kwayo paStaphylococcus aureus, nzira iyi inovhura mukana wekutsvaga dzimwe simbi ne organic biomolecules kuti vawane masisitimu akafanana ane hunhu hwakasiyana. Kutaura zvazviri, timu iyi inoratidza kuti, mune ramangwana, vanogona kugadzira zvinhu zvitsva zvine basa rekuuraya fungus, rekurwisa kenza kana rekuuraya utachiona yakagadziriswa zvichienderana nezvinodiwa zvakasiyana zvekiriniki.
Nzira iri nyore, inoshanda, uye isina utsi hwakawanda
Chimwe chezvinhu zvinonyanya kusimbiswa neavo vane basa rekugadzira izvi ndechekuti maitiro ekugadzira aya madiki-diki haadi matekiniki akaomarara kana mamiriro ezvinhu akaipisisa. Pane kudaro, vakagadzira nzira iri nyore yekugadzira iyo inoitwa muchikamu chimwe chete uye mureactor imwe chete, chimwe chinhu chakakosha kana kugadzirwa kukuru kuchizofungwa nezvako mune ramangwana.
Maitiro acho anotanga kubva ruthenium inotangiraKureva kuti, chinhu chine simbi chinoshanda senzvimbo yekutanga kugadzira nanoparticles, uye chinosanganisa izvi nemorekuru inobva kuuracil yakawanikwa kubva kuDNA. Iyi biomolecule ine basa rakapetwa kaviri: pamusoro pekusunga pamusoro pesimbi, inoshanda se "mold" chaiyo inodzikamisa uye inodzora saizi yezvikamu sezvazvinoumbwa.
Kuenzanisa kwakashandiswa nevaongorori kwakajeka zvikuru: uracil derivative inoshanda se chinhu chikuru chiri muresipiSezvo ruthenium ichiwedzerwa, chikamu ichi cheorganic chinotungamira kuti maatomu esimbi anoungana sei, zvichikurudzira kuumbwa kwezvidimbu zvidiki zvakanyanya uye kudzivirira kuumbwa kwematombo makuru ayo aizorasikirwa nekushanda kwawo kwakawanda. Izvi zvinoguma nehuwandu hwezvinhu zvidiki zvakafanana.
Kubva pakuona kunoshanda, nzira iyi inopa zvakanakira zvakawanda: Inoitwa patembiricha yakaderera, inoderedza kugadzirwa kwemarara asina basa, uye inoisa maitiro ese mu reactor imwe chete.Hunhu uhwu hunoita kuti ive sarudzo iri nyore yekuwedzera uye inogona kuramba iripo kupfuura mamwe masisitimu ekugadzira zvinhu zve nanomaterial, uko matanho akawanda, mamwe ma reagents, kana mamiriro ekupisa anowanzo dikanwa.
Kugadzirisa saizi yezvikamu zvemuviri ndiko kwakakoshawo pamaitiro avo ehupenyu. Muchiitiko ichi, kugona kugadzirisa nekuchengetedza saizi diki kwazvo kunoenderana zvakananga nekushanda kwavo pakurwisa mabhakitiriya akadzidzwa, sezvakazosimbiswa nekuyedza kwerabhoritari kuenzanisa nanoparticles dzedhayamita dzakasiyana.
Ruthenium nanoparticles idzi dzakaita sei uye dzakarongwa sei?
Pakangogadzirwa zvinhu zvacho, timu yekutsvagisa yakashandisa nzira dzakasiyana-siyana dzekutsanangura kuti vaone kana vakawana zvavaitsvaga zvechokwadi. Chinangwa chekutanga chaive chekusimbisa kuti saizi uye chimiro che nanoparticlesPachinangwa ichi, nzira dze microscopy dze high-resolution dzinokwanisa kuona maumbirwo paatomu scale dzakashandiswa.
Vachishandisa maikorosikopu emaerekitironi, masayendisiti akasimbisa kuti zvikamu izvi zvaive diki kwazvo, rakajeka uye rine chimiro chemukati chakarongekaKurongeka kwemaatomu mukati mayo kwakaratidza maitiro akaita sekristaro ayo vaongorori vanoenzanisa nekurongeka kwakajairika kwemasero muhuchi. Magadzirirwo aya emukati anobatsira kuti zvidimbu zvirambe zvakagadzikana uye zvinodzivirira kuti zvisapararire kana kuungana zviri nyore.
Pamwe chete nekucherechedza zvakananga, chikwata ichi chakaitawo kuverenga kwedzidziso uye kutevedzera uchishandisa maturusi epamusoro ekombiyutaMaitiro aya akaita kuti zvikwanisike kudzidza kuti molekyuri inobva kuuracil inobatana sei pamusoro pe ruthenium nanoparticles, rudzii rwezvisungo zvainogadzira, uye kuti chifukidziro ichi chinokanganisa sei nharaunda yemakemikari yesimbi.
Ongororo iyi yakabatana, iyo inobatanidza mhedzisiro yekuedza uye mamodheru edzidziso, inobatsira kunzwisisa zvakadzama hukama huripo pakati pechimiro chezvinhu uye basa rayo rekurwisa utachionaSaka, hazvingozivikanwi chete kuti tunhu tudiki tunoshanda kurwisa mabhakitiriya ari kurwiswa, asiwo kuti ndeapi maitiro chaiwo ekugadzirwa kwatwo anoita seakakosha kuti izvi zviitike.
Kunzwisisa ruzivo urwu kwakakosha kana, gare gare, maparamita akadai serudzi rwesimbi, organic ligand, kana saizi yezvikamu zvichizogadziriswa kuti zvigadzirise sisitimu iyi kune mamwe mashandisirwo ezvekurapa. Mupfungwa iyi, basa iri haringogumiri pakutsanangura nyaya yakazvimiririra, asi rinopa zviratidzo zvekuti ndezvipi zvinhu zvinofanirwa kuchengetwa uye kuti ndezvipi zvinogona kuchinjwa mune dzimwe shanduko dzemangwana.
Mishonga inorwisa utachiona inonyanya kusarudza Staphylococcus aureus
Muedzo wekupedzisira wekuongorora kugona kwezvikamu zvidiki zve nano waisanganisira kuyedza maitiro azvo uchishandisa zvinhu zvakasiyana-siyana zvekutarisa. Vaongorori vakaenzanisa chinhu chinobva kuuracil yakaparadzana, ruthenium complex yakafanana, nanoparticles dzisina kuputirwa, uye zvivako zvakakura nezvidimbu zvakagadzirirwa chidzidzo ichi.
Zvabuda zvaive pachena: Zvidimbu zvidiki chete zvakaputirwa nemorekuru inobva kuuracil ndizvo zvakaratidza kushanda kwakanaka kwekurwisa mabhakitiriya.Mimwe mhando, ingave nekuda kwekushaikwa kwebiomolecule, saizi yakakura, kana kuvapo kwayo sezvikamu zvakasiyana, haina kupa mhedzisiro imwechete paStaphylococcus aureus.
Uyezve, chiito chakaonekwa chakanga chisina kusarura. Kuongororwa kwemurabhoritari kwakaratidza kuti tunhu tudiki utwu twakaita basa nenzira chaiyo. inonyanya kusarudza Staphylococcus aureus, isingaratidzi kushanda kwakakodzera pakurwisa mamwe mabhakitiriya. Izvi zvinonyanya kufadza nekuti mishonga inorwisa mabhakitiriya inoshandiswa zvakanyanya ine mhando dzakasiyana-siyana uye inogona kukanganisawo tupukanana tunobatsira.
Kubva pamaonero ekiriniki, kuva nemishonga inotarisa pathogen chaiyo kunogona kubatsira kuderedza migumisiro yakaipa uye kuderedza kumanikidzwa kwevamwe mabhakitiriyaIzvi zvinogona kubatsira kuderedza kupararira kwekusakwanisa kurwisa utachiona. Sezvakataurwa nevaongorori, imwe yenzira dziri kuongororwa pasi rose ndeyekugadzirwa kwezvinhu zvinoshanda nenzira yakanyanya kunangwa.
Maitiro aya anoenderana nemaitiro ekurapa kwakagadzirirwa rudzi rwehutachiona. Kunyangwe pachine rwendo rurefu kubva pakuedza murabhoritari kusvika pakushandiswa kwevarwere, data rakawanikwa rinoratidza kuti Zvinokwanisika kugadzira zvinhu zve nanomaterials kuitira kuti zvishande kurwisa tupukanana twakanyanya., pfungwa inogona kushandiswa mune dzimwe nzvimbo dzakaoma dzezvirwere.
Matanho anotevera uye zvingangove zvichishandiswa mune zvekurapa muEurope
Mushure mekuratidza kushanda uye kusarudzwa kwezvikamu izvi zvidiki murabhoritari, boka rekutsvagisa rave kutoshanda pa musanganiswa mutsva we biomimetic unobatanidza mamwe ma organic biomolecules nesimbi dzakasiyanaChinangwa ndechekuwedzera huwandu hwezvinhu zviripo uye kutsvaga kuti ndeapi marudzi angabatsira zvakanyanya zvichienderana nerudzi rwehutachiona kana kuti nyama yakanangana nayo.
Pakati pemitsetse inogona kusimudzirwa pane zvinhu zvine basa rekudzivirira fungus kana rekurwisa kenzaPamusoro pemasisitimu ekurwisa utachiona anotarisana nemamwe mabhakitiriya asingaurayiwi anowanikwa muzvipatara zveEurope, kuchinjika kwenzira iyi, zvichibva pakusanganiswa kwesimbi ne organic ligand, zvinoita kuti dhizaini yacho ienderane nematambudziko akasiyana ehutano.
Mumamiriro ezvinhu eEurope, uko Kusakwanisa kurwisa mabhakitiriya chinhu chinonyanya kukosha pahutano hwevanhu Kumasangano akaita seEuropean Centre for Disease Prevention and Control (ECDC), kufambira mberi kwerudzi urwu kunosimbisa basa renzvimbo dzekutsvagisa dzeSpain, Portuguese, French, neGerman mukutsvaga mhinduro dzakajairika. Spain, ine simba rayo repamusoro remishonga inorwisa mabhakitiriya mune dzimwe nzvimbo dzekiriniki, inogona kubatsirwa zvikuru nezvishandiso zvitsva zvinobatsira kudzivirira hutachiona hwakawanikwa muchipatara.
Kubva kuAndalusia, rutsigiro rwemasangano kuburikidza neBazi reYunivhesiti, Tsvagiridzo neKugadzira Zvinhu zvitsva rwakabvumira kuti chirongwa ichi chiitwe nemusanganiswa we mari yedunhu uye zviwanikwa zveInstitute of Chemical ResearchKuzvipira uku kwekushandisa sainzi kumatambudziko chaiwo ehutano kunosimbisa hukama huripo pakati pemarabhoritari nezvinodiwa chaizvo zvehurongwa hwehutano.
Kunyangwe zvichiri kutanga kutaura nezvekushandiswa kwekiriniki nekukurumidza, basa iri rinoratidza kuti zvinokwanisika kugadzira zvidimbu zvidiki zvesimbi zvakagadzirwa nemaoko kuti zvibate mabhakitiriya chaiwo emuchipataraUchishandisa nzira dziri nyore dzekugadzira uye maitiro anoshanda, zvinhu izvi, kana zvikasimbiswa muzvidzidzo zveramangwana uye miedzo yepamberi pekiriniki, zvinogona kubatanidzwa muzvizvarwa zvitsva zvekurapa, machira epamusoro pezvipatara, kana zvishandiso zvekurapa zvine hunhu hwakasiyana hwehutachiona.
Kana zvabatanidzwa, tsvakiridzo iyi yakatungamirwa kubva kuSeville inoratidza kuti kusanganiswa kwekemistri, nanotechnology uye biology kunogona sei kutungamirira ku Nzira itsva dzekudzivirira hutachiona husingarapiki muzvipatara, ichivhura mukana wekugadzirisa rimwe rematambudziko makuru ehutano muSpain neEurope nekushandisa zvimwe zvishandiso zvisiri mishonga yechinyakare inorwisa mabhakitiriya.
