Chikwata kubva kuNational Autonomous University yeMexico yakagadzira recombinant antivenin inokwanisa kudzora chepfu kubva. nyoka dzine ngozi zvikuru muAfricazvinosanganisira mhungu, mamba, uye rinkhals, nemhedzisiro inodarika gadziriro dzechinyakare dzinobva whey.
Kubudirira, mhedzisiro yekubatana kwenyika uye yakaburitswa mukati magazini inonzi Nature, inotarisa pane nanobodies inogadzirwa necamelid inogadzirwa murabhoritari, nzira inovimbisa kuchengetedzwa kwakanyanya, kusimba uye scalability, nekufarira kwakajeka kwe Utano hwepasi rose hweEurope nekuda kwekukanganisa kwayo kubatira pamwe nemishonga yekufamba.
Zvakawanikwa nevatsvakurudzi
Kugadzirira kutsva kunodzivirira kubva kune dzakasiyana siyana neurotoxins uye cytotoxins iripo muhuturu hwe mhungu, mamba uye rinkhals, nyoka nhatu dzinouraya zvikuru mukondinendi yeAfrica, chipfuro chakaoma kuvhara nemaserum akajairika.
Mune miedzo yepreclinical, antivenin yakadzivirira kufa uye kuderedza kukuvadzwa kwenyama yemunharaunda, dambudziko iro marapirwo emazuva ano haadzore zvakanaka; zano iri rakaratidza kuchengetedzwa kukuru uye kuenderana pakati pemabheti zvichienzaniswa nezvigadzirwa zveplasma yemhuka.
Chirongwa ichi chakagadziridzwa paine masayendisiti makumi matatu nevatatu kubva kunyika dzakasiyana siyana kusanganisira Biotechnology Institute yeUNAM ne Technical University yeDenmark, iyo inosimbisa chiyero chayo uye yakazvimiririra kusimbiswa.
Iyo inoshanda sei: camelid nanobodies
Hwaro hweantivenin ndeye nanobodies inotorwa kubva kune masoja ekudzivirira chirwere llamas uye alpacas, yakagadzirwa uye yakagadzirwa kuti ione chepfu yakakosha muhuturu ine hukama hwepamusoro.
Nekuti inogadzirwa zvachose mukurima masisitimu, pasina majekiseni emhuka, kugadzira kunogona kuva scalable, yunifomu, uye inogona kutengeka zvakanyanya, yakabatana nemazuva ano bioproduction zviyero.
Ndiani akasaina chidzidzo ichi uye chakaburitswa kupi?
Iyo IBt-UNAM iri kutora chikamu Edgar Neri Castro, Alejandro Alagón Cano uye mudzidzi watenzi Alid Guadarrama Martínez, tichibatsirana ne Melisa Benard Valle, mukuwirirana nerabhoritari ye Andreas H. Laustsen (Technical University yeDenmark).
Chinyorwa ichi, chakanzi "Nanobody-based recombinant antivenin for cobra, mamba and rinkhal bites", chakasainwawo ne Shirin Ahmadi y Nick J. Burlet, pakati pevamwe; inogona kubvunzwa muNature kuburikidza neiyi link: kuwana kudzidza.
Hutano mutoro uye kukosha kweSpain neEurope
Kurumwa nenyoka a kuregeredzwa kwehosha dzinopisa zvinocherechedzwa neWHO sekukonzera mazana ezviuru ekufa nekuremara gore rega rega, kunyanya kumaruwa uko kusingawanikwe kurapwa.
KuEurope, kusimudzira uku kwakakosha nekuda kwekukanganisa kwayo hutano hwepasirese, mukuchengetwa kwe vafambi nevashandi vanobatsira, uye mumibatanidzwa inobvira yekugadzira nekupa; nzira yekudzora ichasanganisira miedzo yekiriniki uye, kana nguva yasvika, kuongororwa kwenyika dzese uye prequalification maitiro.
Chii chinotevera?
Chikwata chinoronga kukwidziridza kusanganiswa kwenanobodies uye hukuru-hukuru hwekugadzira, ukuwo ichienda kliniki applicationnechinangwa chekuunza chigadzirwa chakachengeteka, chinoshanda uye chinowanikwa kunzvimbo kwachinonyanya kudiwa.
Iine modular chikuva chinobvumira kusanganisa nhamba yakatsanangurwa yemasoja ekudzivirira chirwere, chikumbiro ichi chinotsvaga kutsiva maumbirwo akaomarara anoenderana neplasma yemhuka, inopa. kugadzikana kwemhando uye mari irimo kuvandudza mhinduro kune chepfu.
Iyo yekutanga inoisa biotechnology seyakakosha kurwisa chepfu yekurumwa nenyoka: antivenin. recombinant, inowirirana uye scalable iyo inovhura musuwo wekurapa kwakachengeteka uye kubatana kutsva pakati peLatin America, Africa neEurope.