Sainzi munguva pfupi yapfuura yaita danho guru mukuedza kugadzirisa dambudziko guru muhutano nhasi: kushaikwa kwevanopa rubatsiro. Chikwata chevaongorori chakawana kuberekwa kwechirwere chekutanga. nguruve yakaumbwa neklone ine shanduko dzemajini chaiyo yekuona kuti nhengo dzavo dzinoshanda nevanhu, zvichiratidza shanduko huru mukutsvagurudza kwezvekurapa kunze kwemasimba makuru akajairika.
Mukuita uku, majini matatu anowanzoita kuti muviri wemunhu urambe chero nyama yekunze akabviswa, izvo zvinoita kuti kukura uku kuve muchikwata chakasarudzwa chatove ne United States neChinaKunyangwe nhau dzakatangira kuArgentina, zvadziri kuitika ndezvepasi rose, sezvo nzira yakashandiswa ichivhura mukana wekuti nzvimbo dzekutsvagisa muEurope neSpain dziitewo zvakafanana kuti dzideredze runyorwa rwevanhu vakamirira rusingaperi.
Sei nguruve dzichida kuponesa hupenyu hwevanhu?
Nzira inozivikanwa se kuiswa kwe xenotransplantationKuisirwa kwemasero, nyama, kana nhengo kubva kumhuka kuenda kumunhu, kwakawana mukana wakakodzera munguruve. Izvi hazvisi zvetsaona, asi nekuti mhuka idzi dzinoratidza kufanana kwedu, pamwe nekuva nekubereka nekukurumidza kunoita kuti tsvakurudzo ibudirire.
Dambudziko guru ragara riri rekuti masoja edu ekudzivirira muviri anoona nhengo yenguruve semushonga unorwisa nguruve zvachose uye anoiparadza mumaminitsi mashoma. Kuti izvi zvisaitike, masayendisiti eYunivhesiti yeBuenos Aires neYunivhesiti yeSan MartÃn vakashanda pamwe chete nekambani itsva yeCrofaBiotech, vachishandisa CRISPR-Cas9 tekinoroji kugadzirisa DNA yenguruve diki uye kuita kuti dzisaonekwe nedziviriro dzedu.
Mainjiniya eTriple Knockout
Chinoita kuti chifananidzo ichi chive chakakosha ndechekuti DNA yacho yakagadzirwa pasi pepfungwa yekuti kugogodzwa katatuMumutauro wesainzi, izvi zvinoreva kuti majini matatu chaiwo anokonzera mhinduro yekudzivirira muviri iyo inowanzo paradza kuisirwa kwemasero pakati pemarudzi akasiyana "akabviswa".
Kubudirira kwechirongwa ichi hakusi chete mukubereka mhuka, asiwo pakuti mhuka iyi yakaberekwa ikarerwa ine hutano pasi pekutarisirwa kwakasimba kwemhuka. Sekureva kwenyanzvi dzakabatanidzwa, dzakadai saAdrián Mutto, danho iri rinotibvumira kurota remangwana ratisingavimbi nerupo rwevanhu vanopa mhuka, avo huwandu hwekuwanikwa kwavo husingakwanise kufukidza huwandu hwemhuka idzi. gumi muzana yezvinodiwa pasi rose, sekureva kweWHO.
Kuvhiyiwa kwakanyatsogadzirwa nemazvo
Rwendo kubva murabhoritari kuenda kudanga renguruve rwave rwuri basa guru rekugadzira mainjiniya ekuvhiya. Kusiyana nekuiswa kwembeu nenzira yechinyakare, munyaya iyi a laparotomy isinganyanyi kupindira mumuviri kuisa mazai akagadziriswa uye akaberekeswa zvakananga mumugero wechisikigo unobatanidza ovary nechibereko chembeu yenguruve inogamuchira.
Nzira iyi inobvumira kusvika Mazai akagadziriswa zana nemakumi maviri mukuita kumwe chete, zvichiita kuti pave nebudiriro yakakura kupfuura nzira dzechinyakare. Marcelo Acerbo, nyanzvi yekubereka nguruve, akataura kuti vane basa rekutarisira kubata pamuviri nekubereka, vachiona kuti nguruve diki dzaberekwa mumamiriro akanaka ekurerwa kwadzo munzvimbo dzine kuchengetedzwa kwakanyanya.
Miviri iri kudiwa uye mugwagwa uri mberi
Danho rinotevera muchirongwa ichi chikuru nderekuwedzera mamwe magadzirirwo emajini, kusvika pagumi kana gumi nemaviri ekuchinja. Izvi zvinosanganisira kuvharira kukura kwehomoniIzvi zvakakosha kudzivirira moyo wenguruve kana chiropa kuti chisakure zvakanyanya mumuviri wemunhu, sezvo mhuka yakakura inogona kurema kupfuura makirogiramu mazana maviri.
Vari kutoshanda nemarudzi madiki, anozivikanwa semamini-pigs, ane nhengo dzakakodzera varwere vevana. Chinangwa chikuru ndechekugadzira nzvimbo yekuberekesa nhengo dzakachengeteka apo mhuka dzinoberekana nenzira yechisikigo uye dzinopa shanduko idzi dzemajini kuvana vadzo, zvichibvisa kudiwa kwekugadzira magene ega ega kumurwere wega wega.
Tsvagiridzo iyi inoratidza kutanga kwechikamu chekusimbisa chichagara kwemakore akati wandei uye chinoda zvidzidzo zvakakura zve preclinical tisati taona nhengo yekutanga yenguruve ichishanda mumunhu zvakanyanya. Ruzivo rwazvino rwunovimbisa zvikuru, sezvo bvunzo dzekutanga dzichiratidza kuti masoja emuviri evanhu haazive nhengo iyi seyekunze pakati pe... makumi manomwe nemakumi masere muzana yemasero akagadziriswa, izvo zvinomiririra tariro chaiyo kune zviuru zvevanhu vanomirira kuisirwa masero gore rega rega.