Chikwata chepasirese chaona kwakachengetwa hupenyu hwebundu rega rega uye kuti ungaverenge sei: mu epigenome, kuburikidza. kuchinja methylation mamakisi iyo inoshanda sechinyorwa chenhoroondo chinokwanisa kuratidza zvekare kenza.
Kutenda kune computational nzira, yakaedzwa mukati 2.000 samples dzeleukemias uye lymphomas uye yakaburitswa mujenari Nature, masayendisiti anovakazve kwakabva bundu uye kufungidzira kuti richaita sei, chimwe chinhu chinonyanya kubatsira pakugadzirisa manejimendi ekiriniki yemurwere wega wega.
Zvinorevei kutaura nezve 'black box' yegomarara?
Iyo epigenome ndiyo seti yemakomponi uye mapuroteni ayo, pasina kushandura kutevedzana kweDNA, modulate kuti ndeapi majini anovhurwa kana kuvharwa; muchirongwa ichi, DNA methylation Inoshanda senge switch inogadzirisa genetic chiitiko.
Chinhu chitsva ndechekuti mabhureki aya haangotonge chete, ivo zvakare Vanochengeta ruzivo pamusoro pekuzivikanwa uye nhoroondo yebundu: parakatanga, kukura kwarakaita sei, uye kuti maseru aro akachinja sei nekufamba kwenguva.
Kwemakore, mazhinji ematanho aya aitaridzika seruzha rusina kurongeka pamagirafu; ikozvino, mienzaniso yakakodzera inoratidza kuti iyi inonzi ruzha kutevedzana kwezviitiko iyo inogona kududzirwa nemazvo.
Kunzwisisa iyi epigenetic 'black box' inotitendera kuti tibve pamufananidzo uchienda kune bhaisikopo regomarara, chimwe chinhu chakakosha tarisira chiitiko chako chinotevera chekiriniki uye ita sarudzo dzekurapa nekuwedzera mamiriro.
Kubva pamuenzaniso wemasvomhu kuenda kuEVOFLUx algorithm
Mwoyo wekubudirira ndeye algorithm inonzi EVOFLUx, yakagadzirirwa kubvisa zviratidzo zvenguva kubva kumethylation profiles uye kuvashandura kuita zviyero zvebundu rinobva, kukura, uye heterogeneity.
Kure nekuve generative AI, iyo nzira inosanganisa advanced statistical modelling -kusanganisira Bayesian inference-ine reanalysis yeyakambogadzirwa epigenetic data, ikozvino inoonekwa kuburikidza neimwe lens.
Chirongwa ichi chakatungamirwa nezvikwata zveClÃnic-IDIBAPS muBarcelona neCancer Research Institute muLondon, nevaongorori vakaita sa Iñaki MartÃn-Subero, Trevor Graham, uye vanyori vokutanga Calum Gabbutt naMartà Duran-Ferrer.
Chii 2.000 zviitiko zve leukemia uye lymphoma zvinoratidza
Inoshandiswa kune yakakura kiriniki cohort, iyo nzira inofungidzirwa zvakadzama apo bundu rimwe nerimwe rakatanga, kumhanya kwayo kwekuwedzera uye dhigirii rekusiyana kwemasero, matatu matemo anosarudza hukasha hweramangwana.
Nekuwana kusingazivikanwe nhoroondo dzekiriniki, iyi epigenetic yapfuura yaive yakabatana nekushanduka chaiko kwevarwere, zvichisimbisa izvozvo. zvikamu zvekutanga zvinoratidza kufungidzira gare gare.
Mune chronic lymphocytic leukemia, uko kuongorora kunowanzova nzira inosarudzwa, maitiro anobvumira kutarisira. nemakore asara nguva iyo kurapwa kuchave kwakakodzera.
Kunyangwe kusimbiswa kwakanangana nekenza yehematological, timu inopokana kuti nzira yacho inochinjirwa kumamota akasimba-ane magadzirirwo-uye izvo. liquid biopsy inogona kufambisa kushandiswa kwayo mukuita chaiko.
Clinical utility, mari uye dziviriro
Kuve ne tumor logbook kunovhura musuwo wekugadzirisa kurapa kwakanyanya: kana kukura kuri kunonoka uye kwekare, nzira shoma yehasha inogona kukwanaKana bundu racho richangobva kuitika uye richikurumidza kukura, zvinokurudzirwa kuita zvakanyanya nesimba.
Imwe poindi mukufarira ndeye mutengo wakaderera yehunyanzvi ichienzaniswa nedzimwe nzira, ichiita kuti ishande kune zvirongwa zvekiriniki ine zviwanikwa zvishoma.
Nekudaro, timu pachayo inosimbisa kuti haisati yagadzirira kushandiswa kwemaitiro: chishandiso chinoda kuunzwa kumusika, chakasimbiswa mune zvimwe. mhando dzekenza uye kukunda matanho ekudzora.
Nyanzvi dzekunze, dzakadai saManel Esteller, dzinokoshesa nzira yacho sekuvimbisa, asi yeuka kuti ibasa kunyanya dzidziso izvo zvinoda kumwe kuyedza kusimbiswa uye kuenzanisa neatove aripo single-sero tekinoroji.
Kubatana kwakakura uye rutsigiro kubva kune akati wandei masangano
Chidzidzo ichi chikamu cheClÃnic Barcelona Comprehensive Cancer Center uye yakambotora chikamu che 21 vaongorori kubva ku15 masangano munyika shanu, dzinosanganisira Spain, United Kingdom, Sweden, Switzerland neUnited States.
Basa rawana rutsigiro kubva kune AECC, Cancer Research UK, La Caixa Foundation, ERC, uye NIH, musanganiswa unoratidza kuzvipira kune chaiyo oncology uye kuwedzera maturusi anobatsira kukiriniki.
Nharaunda yesainzi yakaratidza kuti kushandura methylation profiles kuita a nhoroondo yekushanduka kwebundu inoenderana neakasimba maonero egomarara uye inovhura nzira dzekufungidzira uye nekutarisa kwakasimba.
Ne "kuverenga" uku kwekare kwakanyorwa muepigenome, oncologists vaigona kuwana nguva yekuita zvirinani: mepu yemugwagwa iyo, nekumwe kusimbiswa uye kusvetuka kwekudzidzira, inoshuvira kuita. kuenda mberi kwechirwere uye gadzirisa mishonga yemunhu.
